Alert: Fluoroquinolone can cause liver damage

Health Care 120 Comments

In a prospective study conducted by the Drug-Induced Liver Injury Network, 12 of 679 patients who had received a fluoroquinolone  (ciprofloxacin, moxifloxacin, levofloxacin, and gatifloxacin) had hepatotoxicity.

  • Seven had fever, rash, and eosinophilia
  • Four had hepatocellular injury, 4 cholestatic injury, and 4 both. All 4 with both had mild disease without jaundice
  • Two out of 4 patients with hepatocellular injury and jaundice died; one of acute liver failure.
  • One patient with cholestatic injury developed vanishing bile duct syndrome and required liver transplantation.

(Ref: Orman ES, Conjeevaram HS, Vuppalanchi R, et al. Clinical and histopathologic features of fluoroquinolone-induced liver injury. Clin Gastroenterol Hepatol 2011;9:517).