And now CPAP rebound

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Obstructive sleep apnea (OSA) and its associated complications recurred rapidly after discontinuation of continuous positive airway pressure (CPAP), results of a small randomized trial showed. After two weeks without CPAP, the number of arousal events per hour had more than tripled, and apnea-hypopnea events had increased 17-fold. Both measures remained unchanged in patients who continued CPAP. By the end of the study, endothelial function had decreased significantly, and morning blood pressure, heart rate and urinary catecholamines all increased significantly compared with patients who remained on CPAP.

“We found that CPAP withdrawal was associated with a return of OSA by the first night,” Malcolm Kohler, MD, of University Hospital Zurich in Switzerland, and coauthors reported online in the American Journal of Respiratory and Critical Care Medicine. (MedPage)