Ondansetron may cause abnormal heart rhythms

Health Care, Medicine Comments Off

In September 2011, the US FDA issued a warning that ondansetron may prolong the QT interval, which can lead to abnormal and potentially fatal arrhythmias including torsade de pointes.
The FDA recommended that
• Ondansetron be avoided in patients with congenital long QT syndrome.
• EKG monitoring be performed in patients with hypokalemia or hypomagnesemia.
• EKG monitoring be done in heart failure, bradyarrhythmias and in patients taking other drugs that can lead to QT prolongation.