Do not add aspirin in Polypill

Health Care, Medicine Comments Off

A new meta-analysis said to provide “the largest evidence to date regarding the wider effects of aspirin treatment in primary prevention” has shown that cardiovascular benefits are offset by an elevated risk of bleeding.

Dr Kausik Ray at St George’s University of London, UK said that he does not recommend aspirin use in primary prevention. And it certainly should not be put in a polypill for mass use. The new analysis, published online January 9, 2012 in the Archives of Internal Medicine, included nine randomized placebo-controlled trials with a total of 100 000 participants. Results showed that during a mean follow-up of six years, aspirin treatment reduced total cardiovascular events by 10%, driven primarily by a reduction in nonfatal MI, but there was a 30% increased risk of nontrivial bleeding events. The number needed to treat to prevent one cardiovascular event was 120, compared with 73 for causing a nontrivial bleed. [HeartWire]