Daily aspirin to prevent heart disease may increase risk of GI or cerebral bleeding

Health Care, Medicine Comments Off

JAMA has raised a red flag, saying the risk of bleeding even from low dose aspirin everyday is greater than they thought.

The study included more than 186,000 people aged 30 or older being treated with low-dose aspirin and more than 186,000 who were not. During six years, more than 6,900 first episodes of major bleeding requiring hospitalization were documented, including nearly 4,500 episodes of gastrointestinal bleeding and nearly 2,500 episodes of brain hemorrhage. Daily prescribed aspirin was associated with a 55% relative increase in the risk of major bleeding — an excess of two bleeding cases per 1,000 patients treated each year.

This bleeding rate is roughly equal to the number of major cardiovascular events avoided in primary prevention for patients with a 10-year risk in the range of 10% to 20%.