H5N1 Bird Flu Pandemic Just Three Mutations Away

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Influenza A virus subtype H5N1, also known as “bird flu”, A(H5N1) or simply H5N1, is a subtype of the influenza A virus which can cause illness in humans and many other animal species. As per scientists the devastating bird flu H5N1 pandemic seems close to be a real threat and is just “three mutations” away from evolving into a strain that could easily transmit from human to human.

The papers revealed with only five mutations (amino acid substitutions), or four mutations plus reassortment, bird flu can become transmissible between mammals — and potentially humans. Currently, bird flu can be transmitted from birds to humans, but not from humans to humans. The findings were published in the journal Science

Box warning on label as well as package insert and other promotional literature of formulations containing Nimesulide

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It may be stated that the manufacture, sale and distribution of Nimesulide formulations for human use in children below 12 years of age was prohibited under Section 26A of Drugs and Cosmetics Act ,1940 vide Gazette Notification no. GSR 82(E) dated 10.02.2011.

The DTAB in its 60 meeting held on. 10.10.2011 considered the use of Nimesulide in population of 12 years and above and after deliberations recommended that the following Box Warning should be mentioned on label as well as package insert and other promotional literature of formulations containing Nimesulide:

“Use of Nimesulide should ordinarily be restricted to 10 days if longer clinical use is warranted, liver function test should be assessed periodically”.