Uric acid and endothelial dysfunction

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Uric acid and endothelial dysfunction

Uric acid is higher in subjects without diabetes than in those with diabetes. Uric acid is independent variable associated with the endothelium-dependent response in Type 1 diabetes. Normal uric acid is an most important contributing factors to the decreasing endothelium-dependent responses associated with Type 1 diabetes. Uric acid is a new potential marker of microvascular endothelial
dysfunction (Diabet Med 2011 Oct;28(10):1188-93).

Sodium-BP link traced to endothelial harm

For each additional gram of sodium consumed, there was a 1.2 ┬Ámol/L increase (P=0.01) in serum uric acid and a 4.6 mg/day (P<0.001) rise in urine albumin excretion — two markers of endothelial dysfunction, according to John P. Forman, MD, of Harvard Medical School in Boston, and colleagues. Among individuals in the highest tertile of serum uric acid, each 1-g increase in sodium consumption was associated with a hazard ratio for hypertension of 1.09 (95% CI 1.02 to 1.16), whereas the hazard ratio was 0.98 (95% CI 0.89 to 1.08) for those in the lowest tertile (P for interaction <0.001), the researchers reported online in Circulation (Medpage Today).