Fibrates can raise creatinine levels

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In randomized trials, fibrates have been shown to increase creatinine levels. A population-based study showed a link between new fibrate use in elderly and nephrologist consultations and hospital admissions for a rise in creatinine level [1].
In the FIELD trial, the increase in serum creatinine with fenofibrate was reversible on discontinuation, and at the end of the trial fenofibrate treatment appeared to have slowed loss of renal function and reduced proteinuria [2].

1. Zhao YY, Weir MA, Manno M, et al. New fibrate use and acute renal outcomes in elderly adults: a population-based study. Ann Intern Med 2012;156:560.
2. Davis TM, Ting R, Best JD, et al. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study. Diabetologia 2011;54:280.