Polypill may help reduce blood pressure, LDL cholesterol in older patients

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Wolfson Institute of Preventive Medicine in London doctors  tested a polypill consisting of amlodipine, losartan and hydrochlorothiazide  and simvastatin and found that during a three-month period, a single polypill significantly lowered blood pressure and cholesterol levels in 84 study participants who were age 50 and older and had no history of cardiovascular disease. The research was published in the PLoS One.

At 3 months, the reductions were 17.9 mm Hg for systolic blood pressure, 9.8 mm Hg for diastolic pressure, and 54 mg/dL for LDL cholesterol.

Sustained reductions at those levels would be expected to reduce rates of ischemic heart disease events and stroke by a relative 72% and 64%, respectively.