A new drug for diastolic heart failure?

Health Care, Medicine Comments Off

Spironolactone may be useful for patients with heart failure with preserved ejection fraction.

Compared with placebo, spironolactone significantly improved a tissue Doppler derived measure of diastolic function — E/é — within 6 months, a benefit that was sustained at 1 year according to Burkert Pieske, MD, of the Medical University of Graz in Austria.

However, that did not translate into gains in exercise capacity, and peak VO2..

The improvement in diastolic function coupled with improvements in left ventricular mass, it was concluded that spironolactone can be considered in patients with diastolic heart failure for improving cardiac function and blood pressure control.”