Do Heavier HF Patients Live Longe?

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A higher BMI was associated with decreased mortality in certain subsets of patients with acute decompensated heart failure, according to an intercontinental study that supports the existence of a global “obesity paradox.” Overall, a higher BMI was associated with decreased 30-day and 1-year mortality (11% decrease at 30 days; 9% decrease at one year per 5kg⁄m²; P<0.05)¸ after adjustment for clinical risk‚ wrote James L‚ Januzzi Jr‚ MD‚of Massachusetts General Hospital, and his co–authors in the Journal of the American College of Cardiology. Further analysis showed that the protective association was confined to older individuals (>75; HR=0.82‚ p=0.006)‚ decreased cardiac function (ejection fraction < 50%; HR=0.85‚ P<·001)‚ non diabetics (HR=0.86‚ P < ·001)‚ and de novo HF (HR = 0.89‚ P = 0.004).