Top 100 Selling Drugs of 2013

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Hypothyroid medication levothyroxine (Synthroid, AbbVie) was the nation’s most prescribed drug in 2013, whereas the antipsychotic aripiprazole (Abilify, Otsuka Pharmaceutical) had the highest sales, at nearly $6.5 billion. Following levothyroxine as the most prescribed were the cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca), the proton-pump inhibitor esomeprazole (Nexium, AstraZeneca), and the antidepressant duloxetine (Cymbalta, Eli Lilly).

Rounding out the top 10 most prescribed drugs in 2013 (in order) were the asthma drugs albuterol (Ventolin, HFA) and fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), the antihypertensive valsartan (Diovan, Novartis), the attention deficit drug lisdexamfetamine dimesylate (Vyvanse, Shire), the antiepileptic pregabalin (Lyrica, Pfizer), and the chronic obstructive pulmonary disease drug tiotropium bromide (Spiriva, Boehringer Ingelheim).

After aripiprazole, the next best selling drugs in 2013 were Nexium, at $6.1 billion, and the arthritis drug adalimumab (Humira, AbbVie), at $5.5 billion.

Rounding out the top 10 in sales were Crestor ($5.3 billion), Cymbalta ($5.2), Advair Diskus ($5.1 billion), the arthritis drugs etanercept (Enbrel, Amgen; $4.6 billion) and infliximab (Remicade, Centocor; $4.1 billion), the multiple sclerosis drug glatiramer acetate (Copaxone, Teva Pharm; $3.7 billion), and neutropenia drug pegfilgrastim (Neulasta, Amgen; $3.6 billion).
Table 1. Top 100 Drugs by Sales

Rank Drug Brand Chemical Name Sales, 2013
1 Abilify Aripiprazole $6,460,215,394
2 Nexium Esomeprazole $6,135,667,614
3 Humira Adalimumab $5,549,996,855
4 Crestor Rosuvastatin calcium $5,310,818,889
5 Cymbalta Duloxetine hydrochloride $5,219,860,418
6 Advair Diskus Fluticasone propionate $5,121,312,668
7 Enbrel Etanercept $4,681,201,645
8 Remicade Infliximab $4,098,233,242
9 Copaxone Glatiramer acetate $3,697,182,238
10 Neulasta Pegfilgrastim $3,580,364,758
11 Rituxan Rituximab $3,288,614,045
12 Lantus Solostar Insulin Glargine $3,005,681,663
13 Spiriva Handihaler Tiotropium bromide $2,998,207,542
14 Atripla (Efavirenz/emtricitabine/tenofovir disoproxil fumarate) Combination Tablet $2,856,818,557
15 Januvia Sitagliptin $2,843,496,907
16 Avastin Bevacizumab $2,688,414,938
17 Lantus Insulin Glargine $2,556,825,619
18 Oxycontin Oxycodone HCl $2,534,909,675
19 Lyrica Pregabalin $2,415,254,835
20 Epogen Epoetin Alfa $2,280,696,834
21 Celebrex Celecoxib $2,237,658,764
22 Truvada Emtricitabine/tenofovir disoproxil fumarate $2,235,712,145
23 Diovan Valsartan $2,169,819,482
24 Herceptin Trastuzumab $1,938,804,857
25 Gleevec Imatinib Mesylate $1,896,982,614
26 Lucentis Ranibizumab $1,859,463,484
27 Namenda Memantine HCL $1,856,822,750
28 Vyvanse Lisdexamfetamine dimesylate $1,743,115,521
29 Zetia Ezetimibe $1,710,526,476
30 Symbicort Budesonide and formoterol $1,563,242,161
31 Levemir Insulin Detemir $1,547,629,745
32 Suboxone Buprenorphine and naloxone $1,450,554,130
33 Novolog Flexpen Insulin aspart $1,377,221,614
34 Novolog Insulin aspart $1,349,403,122
35 Avonex Interferon beta–1a $1,240,754,136
36 Seroquel Xr Quetiapine fumarate $1,226,532,019
37 Viagra Sildenafil citrate $1,196,812,385
38 Alimta Pemetrexed $1,192,134,813
39 Humalog Insulin Lispro (Human Analog) $1,184,189,487
40 Nasonex Mometasone furoate monohydrate $1,137,402,455
41 Victoza 3–Pak Liraglutide $1,104,811,637
42 Cialis Tadalafil $1,086,355,583
43 Gilenya Fingolimod Capsules $1,059,346,323
44 Flovent Hfa Fluticasone Propionate HFA $1,050,009,900
45 Procrit Epoetin alfa $1,030,419,958
46 Isentress Raltegravir $1,014,678,055
47 Xarelto Rivaroxaban $996,441,091
48 Prezista Darunavir $992,087,940
49 Janumet Sitagliptin Metformin HCL $987,663,598
50 Stelara Ustekinumab $965,072,892
51 Neupogen Filgrastim $958,807,372
52 Orencia Abatacept $957,680,500
53 Renvela Sevelamer Carbonate $955,330,199
54 Reyataz Atazanavir sulfate $934,879,388
55 Vesicare Solifenacin $933,311,254
56 Dexilant Dexlansoprazole $916,401,204
57 Tecfidera Dimethyl fumarate $879,673,483
58 Humalog Kwikpen Insulin lispro injection $879,632,962
59 Synthroid Levothyroxine Sodium $858,725,708
60 Vytorin Ezetimibe and Simvastatin $858,576,112
61 Lunesta Eszopiclone $851,791,226
62 Pradaxa Dabigatran Etexilate Mesylate $836,573,805
63 Benicar Olmesartan Medoxomil $832,276,970
64 Evista Raloxifene $823,647,433
65 Xolair Omalizumab $821,783,471
66 Aranesp Darbepoetin Alfa $809,245,700
67 Prevnar 13 Pneumococcal vaccine 13–valent $806,129,346
68 Sensipar Cinacalcet $786,320,942
69 Xgeva Denosumab $785,725,436
70 Invega Sustenna Paliperidone palmitate $779,834,172
71 Zytiga Abiraterone Acetate $775,269,249
72 Avonex Pen Interferon beta–1a $768,655,140
73 Synagis Palivizumab $767,786,422
74 Betaseron Interferon beta–1 $767,648,290
75 Xeloda Capecitabine $754,133,787
76 Ventolin Hfa Albuterol sulfate $745,629,470
77 Zyvox Linezolid $726,184,205
78 Afinitor Everolimus $721,629,719
79 Gardasil Human Papillomavirus Quadrivalent $710,208,856
80 Zostavax Zoster vaccine live $705,140,729
81 Incivek Telaprevir $701,317,408
82 Sandostatin Lar Octreotide Acetate $697,961,265
83 Aciphex Rabeprazole Sodium $683,359,951
84 Benicar Hct Olmesartan Medoxomil-Hydrochlorothiazide $681,353,719
85 Bystolic Nebivolol $681,318,227
86 Treanda Bendamustine Hydrochloride $679,052,250
87 Focalin Xr Dexmethylphenidate Hydrochloride $660,161,202
88 Erbitux Cetuximab $648,984,405
89 Tamiflu Oseltamivir phosphate $641,134,799
90 Tarceva Erlotinib $640,597,157
91 Pristiq Desvenlafaxine $632,619,542
92 Complera Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate $630,039,312
93 Cubicin Daptomycin $628,034,439
94 Velcade Bortezomib $621,800,823
95 Strattera Atomoxetine $616,604,042
96 Viread Tenofovir Disoproxil Fumarate $599,074,197
97 Stribild Elvitegravir, Cobicistat, Emtricitabine, Tenofovir DF $598,844,153
98 Welchol Colesevelam $573,939,710
99 Combivent Respimat Ipratropium bromide and Albuterol $573,179,772
100 Xifaxan Rifaximin $569,762,570