Sugar-sweetened drinks increase risk of diabetes and metabolic syndrome

Health Care, Medicine Comments Off

A review of epidemiological studies published online November 2 2017 in the Journal of the Endocrine Society has added to the growing evidence of the association of sugar sweetened beverages with chronic lifestyle disorders such as type 2 diabetes hypertension and heart disease. The review which examined the association of sugar sweetened beverages with type 2 diabetes metabolic syndrome and hypertension found that regularly drinking sugar sweetened beverages such as soda and juice contributes to the development of type 2 diabetes and high blood pressure. Most of the studies included in the review found that consumption of sugar sweetened beverages also increased the risk of metabolic syndrome which in turn increased the risk of developing heart disease stroke and diabetes. The review included 36 studies on the cardiometabolic effects of sugar sweetened beverage consumption from the last 10 years. Most of the analyzed studies for metabolic syndrome included individuals who drank more than five sugar sweetened beverages a week while consuming as few as two servings of sugar sweetened beverages a week increased the risk of developing type 2 diabetes. Drinking at least one sugar sweetened beverage a day was associated with high blood pressure. These findings yet again highlight the need to educate the general public the young in particular about the adverse health effects of sugar sweetened beverages who frequently consume foods and drinks high in added sugars. It is very important therefore to raise awareness among the public about the lifestyle diseases prevalent in our country which are now occurring at a younger age and the lifestyle measure by which these disease can be prevented. Source Endocrine Society News Release November 2 2017

Autophagy and Diabetes

Health Care, Medicine Comments Off

Autophagy in diabetes has recently been the focus of research and accumulating evidence has suggested a pathophysiological role for autophagy in diabetes.1 The word autophagy means self eating as it is derived from two Greek words auto meaning self and phagein meaning to eat . Autophagy is a catabolic process by which cells adapt to stress and starvation. It maintains cellular homeostasis by lysosomal mediated degradation and recycling of damaged proteins and organelles such as mitochondria. 2 3 Three types of autophagy are described Macroautophagy microautophagy and chaperone mediated autophagy. The most prevalent of these is macroautophagy.4 Hyperglycemia secondary to insulin resistance is implicated in the pathogenesis of diabetes. In the natural history of type 2 diabetes hypertrophy of the pancreatic 946 cells occurs to compensate for hyperglycemia and insulin resistance occurs early in the disease. As the disease progresses dysfunction and loss of 946 cells occur. 1 Autophagy is now regarded as necessary to maintain the structure and function of pancreatic 946 cells. 5 Autophagy dysfunction is associated with loss of 946 cell mass and function suggesting a possible role in the development and progression of type 2 diabetes. 6 Autophagy may affect insulin sensitivity as mitochondrial dysfunction has been implicated in insulin resistance. 2 Mitochondria dysfunction results in incomplete 946 oxidation oxidative stress accumulation of toxic lipid intermediates and mitochondrial damage. By removing the dysfunctional mitochondria autophagy removes the cycle of oxidative stress and mitochondrial damage.7 Autophagy also has a possible role in regulation of function of insulin target tissues such as skeletal muscle liver and adipose tissue where it protects against oxidative stress in these tissues. 3 The Nobel Prize in Physiology or Medicine 2016 was awarded to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy. References 1. Demirtas L et al. Apoptosis autophagy endoplasmic reticulum stress in diabetes mellitus. Indian J Med Res. 2016 144 4 515 24. 2. Jung HS et al. Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci. 2010 1201 79 83. 3. Barlow AD et al. Autophagy in diabetes 946 cell dysfunction insulin resistance and complications. DNA Cell Biol. 2015 34 4 252 60. 4. Islam MT et al. Autophagic dysfunction in type 2 diabetes mellitus pathophysiology and therapeutic implications. J Diabetes Metab. 2017 8 742 5. Quan W et al. Role of autophagy in the control of body metabolism. Endocrinol Metab Seoul . 2013 28 1 6 11. 6. Mazza S et al. Autophagy and pancreatic 946 cells. Vitam Horm. 2014 95 145 64. 7. Sarparanta J et al. Autophagy and mitochondria in obesity and type 2 diabetes. Curr Diabetes Rev. 2017 13 4 352 69.

Why Lord Ganesha never suffered from diabetes despite a pot belly obesity

Health Care, Medicine Comments Off

Lord Ganesha is always shown with a big tummy and sweets laddoos in one hand. Yet he never had diabetes. A spiritual interpretation to this can be that the big tummy symbolizes retention of all information gathered from listening with two big elephant ears. Sweets mean control of desires. There is a medical interpretation too where the big tummy represents susceptibility of Asian Indians to pot belly obesity and to metabolic syndrome. Abdominal obesity is one of the diagnostic criteria for metabolic syndrome. The sweets denote uncontrolled desire to eat sweets which can be controlled by the offerings fruits and leaves to Ganesha through their antidiabetic properties. Gajananam Bhoota Ganadi Sevitam Kapittha Jambu phalasara bhakshitam Umasutam Shoka Vinasha karanam Namami Vighneswara pada pankajam . Oh Elephant faced worshiped by the existing beings of all living beings tasting the elephant apple kaith and jambolana jamun the Son of Uma destroyer of grief I bow to the lotus feet of Ganesha who is lord of all This main Ganesha mantra can also be interpreted as explaining the antidiabetes properties of the various offerings to Ganesha. Gajananam the big tummy one worshipped by all Bhoota Durva grass and Bilva patra Ganadi in equal quantity Sevitam if consumed Kapittha Kaith Jambu Jamun phalasara fruits bhakshitam to be consumed Umasutam son of Uma Shoka diseases Vinasha karanam get rid of Namami I bow to Vighneswara destroyer of grief pada pankajam feet of lord The mantra talks about four medicinal herbs Durva grass and Bilva patra elephant apple fruit Kaith and Jamun. Durva grass has antidiabetic cholesterol lowering immunomodulatory and anti inflammatory activities. Bilva Patra bel leaves and Elephant apple Kaitha also have antidiabetic properties. Jamun is an antidiabetic antioxidant and DNA protective and is an essential ingredient of most antidiabetic Ayurveda preparations. Disclaimer The views and interpretations expressed in this write up are my own based on listening to many Ayurveda experts.

« Previous Entries